Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Environmental conservation: bystander CD4 T cells keep CD8 memories fresh

Nature Immunology volume 5, pages 873–874 (2004)Cite this article

CD4+ T cells reportedly program CD8+ T cells to develop into suitable memory cells during the primary immune response. However, new data indicate that the maintenance of CD8+ memory T cells requires continuous exposure to bystander CD4+ T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Two models for the function of CD4+ T cells in the maintenance of CD8+ memory.

K.R.

References

  1. Sun, J.C., Williams, M.A. & Bevan, M.J. Nat. Immunol. 5, 927–933 (2004).

    Article  CAS  Google Scholar 

  2. Kaech, S.M. & Ahmed, R. Science 300, 263–265 (2003).

    Article  CAS  Google Scholar 

  3. Janssen, E.M. et al. Nature 421, 852–856 (2003).

    Article  CAS  Google Scholar 

  4. Sun, J.C. & Bevan, M.J. Science 300, 339–342 (2003).

    Article  CAS  Google Scholar 

  5. Shedlock, D.J. & Shen, H. Science 300, 337–339 (2003).

    Article  CAS  Google Scholar 

  6. Bourgeois, C., Veiga-Fernandes, H., Joret, A.M., Rocha, B. & Tanchot, C. Eur. J. Immunol. 32, 2199–2207 (2002).

    Article  CAS  Google Scholar 

  7. Johansen, P., Stamou, P., Tascon, R.E., Lowrie, D.B. & Stockinger, B. Eur. J. Immunol. 34, 91–97 (2004).

    Article  CAS  Google Scholar 

  8. Schluns, K.S. & Lefrancois, L. Nat. Rev. Immunol. 3, 269–279 (2003).

    Article  CAS  Google Scholar 

  9. Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Nat. Immunol. 1, 426–432 (2000).

    Article  CAS  Google Scholar 

  10. Kaech, S.M. et al. Nat. Immunol. 4, 1191–1198 (2003).

    Article  CAS  Google Scholar 

  11. Marzo, A.L. et al. J. Immunol. 173, 969–975 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, 55455, Minnesota, USA

    Sara E Hamilton, Martin Prlic & Stephen C Jameson

Authors
  1. Sara E Hamilton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Prlic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen C Jameson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hamilton, S., Prlic, M. & Jameson, S. Environmental conservation: bystander CD4 T cells keep CD8 memories fresh. Nat Immunol 5, 873–874 (2004). https://doi.org/10.1038/ni0904-873

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0904-873

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing