Transplantation—caught in the crossfire!

“Cross-presentation” can prime CD8+ T cells. A transplantation system now reveals its role in destruction of the host endothelial cells that feed the graft.

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Figure 1: Donor antigens are released from the graft and are then picked up by recipient APCs for presentation on recipient MHC class I.

Bob Crimi

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Waldmann, H. Transplantation—caught in the crossfire!. Nat Immunol 3, 803–804 (2002). https://doi.org/10.1038/ni0902-803

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