The Clonal Selection Theory: what it really is and why modern challenges are misplaced

Historical insight: The clonal selection theory of antibody formation has recently been subjected to challenge from many quarters. A review of its history and that of scientific theories in general points to the importance of distinguishing between the central hypotheses of a theory and its subsidiary implications.

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Figure 1: Burnet's illustration of the CST.

K. R.

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Acknowledgements

I thank K. Schaffner for his helpful discussion of the structure of scientific theories and N. Rose for useful suggestions.

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Silverstein, A. The Clonal Selection Theory: what it really is and why modern challenges are misplaced. Nat Immunol 3, 793–796 (2002). https://doi.org/10.1038/ni0902-793

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