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TIRAP: how Toll receptors fraternize

Nature Immunology volume 2, pages 828–830 (2001)Cite this article

Although some cellular responses induced by TLRs are abolished in MyD88-deficient mice, TLR4, unlike TLR9, can still induce activation of NF-κB and MAPKs. The discovery of a cytoplasmic adapter protein for TLR4, called TIRAP, helps explain this phenomenon.

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Figure 1: Signaling pathway of TLRs.

Bob Crimi

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Authors and Affiliations

  1. Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, 01655, MA, USA

    Philipp Henneke & Douglas T. Golenbock

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  1. Philipp Henneke
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  2. Douglas T. Golenbock
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Henneke, P., Golenbock, D. TIRAP: how Toll receptors fraternize. Nat Immunol 2, 828–830 (2001). https://doi.org/10.1038/ni0901-828

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  • DOI: https://doi.org/10.1038/ni0901-828

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