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Complementing asthma

The complement inflammatory cascade is crucial to our innate ability to ward off infection. Two papers now provide evidence linking C5 and C3a to murine airway hyperresponsiveness, a partial model of human asthma. Surprisingly, these complement proteins appear to have opposite effects.

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Figure 1: Possible involvement of C3 and C5 in allergen-induced airways hyperresponsiveness (AHR).


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Henson, P. Complementing asthma. Nat Immunol 1, 190–192 (2000).

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