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Dead man walking: how thymocytes scan the medulla

Nature Immunology volume 10, pages 809811 (2009) | Download Citation

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The thymic medulla provides a unique milieu for the induction of T cell tolerance. New work now provides a first glimpse of how thymocytes scan this microenvironment and thus maximize their chances of encountering self antigen.

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References

  1. 1.

    & Annu. Rev. Immunol. 25, 649–679 (2007).

  2. 2.

    et al. Nat. Immunol. 10, 823–830 (2009).

  3. 3.

    & Annu. Rev. Immunol. 24, 571–606 (2006).

  4. 4.

    , , & J. Exp. Med. 206, 607–622 (2009).

  5. 5.

    et al. Proc. Natl. Acad. Sci. USA 105, 19869–19874 (2008).

  6. 6.

    , & Proc. Natl. Acad. Sci. USA 106, 10278–10283 (2009).

  7. 7.

    , , , & Proc. Natl. Acad. Sci. USA 105, 657–662 (2008).

  8. 8.

    , , & Proc. Natl. Acad. Sci. USA 105, 15860–15865 (2008).

  9. 9.

    & J. Exp. Med. 200, 1039–1049 (2004).

  10. 10.

    & J. Exp. Med. published online, doi:10.1084/jem.20082449 (29 June 2009).

  11. 11.

    , , , & PLoS Biol. 3, e160 (2005).

  12. 12.

    , , , & Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).

  13. 13.

    , , , & Nature 414, 763–768 (2001).

  14. 14.

    et al. Nat. Immunol. 10, 610–617 (2009).

Download references

Author information

Affiliations

  1. Ludger Klein is with the Institute for Immunology, Ludwig-Maximilian-University, Munich, Germany.  ludger.klein@med.lmu.de

    • Ludger Klein

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DOI

https://doi.org/10.1038/ni0809-809

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