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TH2 bias: Mina tips the balance

Nature Immunology volume 10, pages 806–808 (2009)Cite this article

Tipping the balance of early cytokine production can lead to lineage bias and, potentially, immune-mediated pathology. Mapping of a leishmania-susceptibility region has identified a gene that may determine the extent of T helper type 2 bias in naive helper T cells.

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Figure 1: Mina tips the balance in TH2 bias.

References

  1. Okamoto, M. et al. Nat. Immunol. 10, 872–879 (2009).

    Article  CAS  Google Scholar 

  2. Grogan, J.L. et al. Immunity 14, 205–215 (2001).

    Article  CAS  Google Scholar 

  3. Baguet, A., Epler, J., Wen, K.W. & Bix, M. J. Exp. Med. 200, 1605–1612 (2004).

    Article  CAS  Google Scholar 

  4. Bix, M., Wang, Z.E., Thiel, B., Schork, N.J. & Locksley, R.M. J. Exp. Med. 188, 2289–2299 (1998).

    Article  CAS  Google Scholar 

  5. Peng, S.L., Gerth, A.J., Ranger, A.M. & Glimcher, L.H. Immunity 14, 13–20 (2001).

    Article  CAS  Google Scholar 

  6. Monticelli, S. & Rao, A. Eur. J. Immunol. 32, 2971–2978 (2002).

    Article  CAS  Google Scholar 

  7. Hodge, M.R. et al. Immunity 4, 397–405 (1996).

    Article  CAS  Google Scholar 

  8. Kiani, A., Viola, J.P., Lichtman, A.H. & Rao, A. Immunity 7, 849–860 (1997).

    Article  CAS  Google Scholar 

  9. Affolter, M., Pyrowolakis, G., Weiss, A. & Basler, K. Dev. Cell 15, 11–22 (2008).

    Article  CAS  Google Scholar 

  10. Cloos, P.A., Christensen, J., Agger, K. & Helin, K. Genes Dev. 22, 1115–1140 (2008).

    Article  CAS  Google Scholar 

  11. Mowen, K.A., Schurter, B.T., Fathman, J.W., David, M. & Glimcher, L.H. Mol. Cell 15, 559–571 (2004).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Saskia Hemmers and Kerri A. Mowen are in the Department of Chemical Physiology and the Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, USA.,

    Saskia Hemmers & Kerri A Mowen

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  1. Saskia Hemmers
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  2. Kerri A Mowen
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Correspondence to Kerri A Mowen.

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Hemmers, S., Mowen, K. TH2 bias: Mina tips the balance. Nat Immunol 10, 806–808 (2009). https://doi.org/10.1038/ni0809-806

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