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Recognition reversal in a spineless scrounger

The recently deduced structures of amphioxus immune-like receptors provide new insights on what is actually required for antigen recognition by antigen receptors.

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Figure 1: Low-resolution representation of some key differences in domain-domain interactions for classical V domains and the amphioxus VCBP3 V1 and V2 V-like domains.

References

  1. Wu, T.T. & Kabat, E.A. J. Exp. Med. 132, 211–250 (1970).

    Article  CAS  Google Scholar 

  2. Poljak, R.J. Nature 256, 373–376 (1975).

    Article  CAS  Google Scholar 

  3. Hernández Prada, J.A. et al. Nat. Immunol. 7, 875–882 (2006).

    Article  Google Scholar 

  4. Kirkham, P.M. & Schroeder, H.W. Semin. Immunol. 6, 347–360 (1994).

    Article  CAS  Google Scholar 

  5. Hamers-Casterman, C. et al. Nature 363, 446–448 (1993).

    Article  CAS  Google Scholar 

  6. Cooper, M.D. & Alder, M.N. Cell 124, 815–822 (2006).

    Article  CAS  Google Scholar 

  7. Pancer, Z. et al. Nature 430, 174–180 (2004).

    Article  CAS  Google Scholar 

  8. Alder, M.N. et al. Science 310, 1970–1973 (2005).

    Article  CAS  Google Scholar 

  9. Pancer, Z., Mayer, W.E., Klein, J. & Cooper, M.D. Proc. Natl. Acad. Sci. USA 101, 13273–13278 (2004).

    Article  CAS  Google Scholar 

  10. Sun, S.C., Lindstrom, I., Boman, H.G., Faye, I. & Schmidt, O. Science 250, 1729–1732 (1990).

    Article  CAS  Google Scholar 

  11. Zhang, S.M., Adema, C.M., Kepler, T.B. & Loker, E.S. Science 305, 251–254 (2004).

    Article  CAS  Google Scholar 

  12. Watson, F.L. et al. Science 309, 1874–1878 (2005).

    Article  CAS  Google Scholar 

  13. Cannon, J.P., Haire, R.N. & Litman, G.W. Nat. Immunol. 3, 1200–1207 (2002).

    Article  CAS  Google Scholar 

  14. Silverman, G.J. & Goodyear, C.S. Nat. Rev. Immunol. 6, 465–475 (2006).

    Article  CAS  Google Scholar 

Download references

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Greenspan, N., Schroeder, H. Recognition reversal in a spineless scrounger. Nat Immunol 7, 797–798 (2006). https://doi.org/10.1038/ni0806-797

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