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Finding the groove

Envisioning how T cells might recognize antigen presented by major histocompatibility complex molecules proved to be a formidable challenge. Pamela Bjorkman describes her journey to provide structural insights into how such recognition is achieved.

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Figure 1: An early (circa 1986) attempt to elucidate MHC-restricted recognition of a viral antigen by T cells.

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Bjorkman, P. Finding the groove. Nat Immunol 7, 787–789 (2006). https://doi.org/10.1038/ni0806-787

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