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It takes nerve to dampen inflammation

Stimulation of the vagus nerve via the α7 nicotinic acetylcholine receptor can dampen macrophage function. This anti-inflammatory pathway seems to signal through the Jak2-STAT3 pathway.

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Figure 1: Cholinergic stimulation ameliorates enteric inflammation during postoperative ileus via α7 nAChR–Jak2 interactions.

Katie Ris


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Metz, C., Tracey, K. It takes nerve to dampen inflammation. Nat Immunol 6, 756–757 (2005).

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