A role for Shc in T cell development was controversial. Two different genetic approaches now show Shc plays a nonredundant and essential function in pre-TCR signaling.
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References
Zhang, L., Camerini, V., Bender, T.P. & Ravichandran, K.S. Nature Immunol. 3, 749–755 (2002).
Luzi, L., Confalonieri, S., Di Fiore, P.P. & Pelicci, P.G. Curr. Opin. Genet. Dev. 10, 668–674 (2000).
Lai, K.M. & Pawson, T. Genes Dev. 14, 1132–1145 (2000).
Migliaccio, E. et al. Nature 402, 309–313 (1999).
Migliaccio, E. et al. EMBO J. 16, 706–716 (1997).
Ravichandran, K.S. et al. Science 262, 902–905 (1993).
Pratt, J.C. et al. J. Immunol. 163, 2586–2591 (1999).
Plyte, S. et al. Oncogene 19, 1529–1537 (2000).
Pacini, S. et al. J. Biol. Chem. 273, 20487–20493 (1998).
Ravichandran, K.S., Lorenz, U., Shoelson, S.E. & Burakoff, S.J. Mol. Cell. Biol. 15, 593–600 (1995).
Northrop, J.P., Pustelnik, M.J., Lu, A.T. & Grove, J.R. Mol. Cell. Biol. 16, 2255–2263 (1996).
Osman, N., Lucas, S.C., Turner, H. & Cantrell, D. J. Biol. Chem. 270, 13981–1396 (1995).
Zhang, W. et al. Immunity 10, 323–332 (1999).
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Palmer, E. Shc: a dominant player after ten seasons. Nat Immunol 3, 710–711 (2002). https://doi.org/10.1038/ni0802-710
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DOI: https://doi.org/10.1038/ni0802-710
