Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Paneth cells—guardians of the gut cell hatchery

Protection of the small intestine from harmful bacteria is a never-ending job. Paneth cells of the intestinal crypts function as prime producers of defensins in response to the microbial onslaught of the gut.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The relationship of small intestinal crypts (bottom) to villi (top).

Cleveland Clinic Foundation

References

  1. Schmidt, G.H., Wilkinson, M.M. & Ponder, B.A. Cell migration pathway in the intestinal epithelium: an in situ marker system using mouse aggregation chimeras. Cell 40, 425–429 ( 1985).

    CAS  Article  Google Scholar 

  2. Ayabe, T. et al. Secretion of microbial α-defensins by intestinal Paneth cells in response to bacteria. Nature Immunol. 2, 113–118 (2000).

    Article  Google Scholar 

  3. Satoh, Y. Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice. Cell Tissue Res. 251, 87–93 (1988).

    CAS  Article  Google Scholar 

  4. Satoh, Y., Ishikawa, K., Tanaka, H., Oomori, Y. & Ono, K. Immunohistochemical observations of lysozyme in the Paneth cells of specific-pathogen-free and germ-free mice. Acta Histochem. 83, 185–188 (1988).

    CAS  Article  Google Scholar 

  5. Ouellette, A.J. et al. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. J. Cell Biol. 108, 1687–1695 ( 1989).

    CAS  Article  Google Scholar 

  6. Jones, D.E. & Bevins, C.L. Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 267, 23216–23225 ( 1992).

    CAS  PubMed  Google Scholar 

  7. Qu, X.D., Lloyd, K.C., Walsh, J.H. & Lehrer, R.I. Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells . Infect. Immunity 64, 5161– 5165 (1996).

    CAS  Google Scholar 

  8. Selsted, M.E., Miller, S.I., Henschen, A.H. & Ouellette, A.J. Enteric defensins: antibiotic peptide components of intestinal host defense . J. Cell Biol. 118, 929– 936 (1992).

    CAS  Article  Google Scholar 

  9. Porter, E.M., vanDam, E., Valore, E.V. & Ganz, T. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infec. Immunity 65, 2396–2401 (1997).

    CAS  Google Scholar 

  10. Wilson, C.L. et al. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113–117 (1999).

    CAS  Article  Google Scholar 

  11. Garabedian, E.M., Roberts, L.J.J., McNevin, M.S. & Gordon, J.I. Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J. Biol. Chem. 272, 23729–23740 (1997).

    CAS  Article  Google Scholar 

  12. Ganz, T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect. Immunity 55, 568– 571 (1987).

    CAS  Google Scholar 

  13. Lemaitre, B., Reichhart, J.M. & Hoffmann, J.A. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms . Proc. Natl Acad. Sci. USA 94, 14614– 14619 (1997).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ganz, T. Paneth cells—guardians of the gut cell hatchery. Nat Immunol 1, 99–100 (2000). https://doi.org/10.1038/77884

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/77884

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing