Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Now you see it, now you don't!

NK cells become cytotoxic upon receiving a signal through their activation receptors. The orphan proteins H-60 and Rae1 have now been identified as ligands for the mouse NKG2D activation receptor. Remarkably they are inducible and may be blocked by a viral protein.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Potential importance of NKG2D ligands in host defense by NK cells.

Bob Crimi

References

  1. Yokoyama, W.M. in Fundamental Immunology Ch. 17(ed. Paul, W. E.) 575– 603 (Lippincott-Raven, New York, 1999).

    Google Scholar 

  2. Karre, K. in Mechanisms of Cytotoxicity by NK Cells (eds Herberman, R.B. & Callewaert, D. M.) 81–92 (Academic Press, Orlando, 1985).

    Book  Google Scholar 

  3. Diefenbach, A., Jamieson, A.M., Liu, S.D., Shastri, N. & Raulet, D.H. Novel ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages . Nature Immunol. 1, 119– 126 (2000).

    CAS  Article  Google Scholar 

  4. Cerwenka, A. et al. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12, 721–727 (2000).

    CAS  Article  Google Scholar 

  5. Cosman, D. et al. The human cytomegalovirus (HCMV) glycoprotein, UL16 binds to the MHC class I-related protein, MICB/PerB11, and to two novel, MHC class I-related molecules, ULBP1 and ULBP2 [Abstr.]. FASEB J. 14, A1018 (2000).

    Google Scholar 

  6. Lanier, L.L. Turning on natural killer cells. J. Exp. Med. 191, 1259–1262 (2000).

    CAS  Article  Google Scholar 

  7. Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727– 729 (1999).

    CAS  Article  Google Scholar 

  8. Wu, J. et al. An activating immunoreceptor complex formed by NKG2D and DAP10 . Science 285, 730–732 (1999).

    CAS  Article  Google Scholar 

  9. Brown, M.G., Scalzo, A.A. & Yokoyama, W.M. in Major Histocompatibility Complex: Evolution, Structure, and Function (ed. Kasahara, M.) 287–301 (Springer-Verlag, Tokyo, 2000).

    Book  Google Scholar 

  10. Chalupny, J. et al. Soluble forms of the novel MHC class I-related molecules, ULBP1 and ULBP2, bind to and functionally activate NK cells. FASEB J. 14, A1018 (2000).

    Google Scholar 

  11. Malarkannan, S. et al. The molecular and functional characterization of a dominant minor H antigen, H-60. J. Immunol. 161, 3501–3509 (1998).

    CAS  PubMed  Google Scholar 

  12. Nomura, M., Takihara, Y. & Shimada, K. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation 57, 39– 50 (1994).

    CAS  Article  Google Scholar 

  13. Tortorella, D., Gewurz, B.E., Furman, M.H., Schust, D.J. & Ploegh, H.L. Viral subversion of the immune system. Annu. Rev. Immunol. 18, 861– 926 (2000).

    CAS  Article  Google Scholar 

  14. Holtermann, O. A., Lisafeld, B. A., Klein, E. & Klostergaard, J. Cytocidal and cytostatic effects of activated peritoneal leukocytes. Nature 257, 228–229 ( 1975).

    CAS  Article  Google Scholar 

  15. Degos, L. et al. All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia. Blood 85, 2643–2653 (1995).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Yokoyama, W. Now you see it, now you don't!. Nat Immunol 1, 95–97 (2000). https://doi.org/10.1038/77878

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/77878

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing