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gp96—The immune system's Swiss army knife

Tumor vaccines comprised of the chaperone gp96 can instigate specific immunity to tumor peptides. A receptor on macrophages for the uptake of peptide-loaded gp96 has been identified as CD91, the α2-macroglobulin receptor.

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Figure 1: Necrotic cells and apoptotic cells exert opposite effects upon antigen presenting cells.

Bob Crimi

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Schild, H., Rammensee, HG. gp96—The immune system's Swiss army knife. Nat Immunol 1, 100–101 (2000). https://doi.org/10.1038/77770

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