Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A novel modifier of regulatory T cells

Nature Immunology volume 10, pages 685–686 (2009)Cite this article

The receptor for the lipid mediator sphingosine 1-phosphate is critical for T cell trafficking. New data show that signaling mediated by this receptor critically controls the development, maintenance and suppressive activity of natural regulatory T cells that express the transcription factor Foxp3.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Treg cell function is controlled by many signaling pathways, including the S1P1-mediated pathway.

References

  1. Sakaguchi, S. et al. Cell 133, 775–787 (2008).

    Article  CAS  Google Scholar 

  2. Liu, G. et al. Nat. Immunol. 10, 769–777 (2009).

    Article  CAS  Google Scholar 

  3. Matloubian, M. et al. Nature 427, 355–360 (2004).

    Article  CAS  Google Scholar 

  4. Patton, D.T. et al. J. Immunol. 177, 6598–6602 (2006).

    Article  CAS  Google Scholar 

  5. Haxhinasto, S., Mathis, D. & Benoist, C. J. Exp. Med. 205, 565–574 (2008).

    Article  CAS  Google Scholar 

  6. Gao, W. et al. Am. J. Transplant. 7, 1722–1732 (2007).

    Article  CAS  Google Scholar 

  7. Zhang, Z. & Schluesener, H. J. Mini Rev. Med. Chem. 7, 845–850 (2007).

    Article  CAS  Google Scholar 

  8. Brinkmann, V. et al. J. Biol. Chem. 277, 21453–21457 (2002).

    Article  CAS  Google Scholar 

  9. Payne, S.G. et al. Blood 109, 1077–1085 (2007).

    Article  CAS  Google Scholar 

  10. Golovina, T.N. et al. J. Immunol. 181, 2855–2868 (2008).

    Article  CAS  Google Scholar 

  11. McHugh, R.S. et al. Immunity 16, 311–323 (2002).

    Article  CAS  Google Scholar 

  12. Sutmuller, R.P. et al. Trends Immunol. 27, 387–393 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Naganari Ohkura and Shimon Sakaguchi are in the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, and World Premier International Research Center, Immunology Frontier Research Center, Osaka University, Suita, Japan. e-mail: shimon@frontier.kyoto-u.ac.jp,

    Naganari Ohkura & Shimon Sakaguchi

Authors
  1. Naganari Ohkura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shimon Sakaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ohkura, N., Sakaguchi, S. A novel modifier of regulatory T cells. Nat Immunol 10, 685–686 (2009). https://doi.org/10.1038/ni0709-685

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0709-685

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing