Dendritic cells are best known as antigen-presenting cells that initiate adaptive immune responses. Three new papers suggest that basophils initiate allergen- and helminth-driven CD4+ T helper type 2 responses by functioning as antigen-presenting cells in draining lymph nodes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The role of β2 integrin in dendritic cell migration during infection
BMC Immunology Open Access 06 January 2021
-
Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial
Journal of the International Society of Sports Nutrition Open Access 02 August 2018
-
Shuang-Huang-Lian prevents basophilic granulocyte activation to suppress Th2 immunity
BMC Complementary and Alternative Medicine Open Access 03 January 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sokol, C.L. et al. Nat. Immunol. 10, 713–720 (2009).
Perrigoue, J.G. et al. Nat. Immunol. 10, 697–705 (2009).
Yoshimoto, T. et al. Nat. Immunol. 10, 706–712 (2009).
MacDonald, A.S., Straw, A.D., Bauman, B. & Pearce, E.J. J. Immunol. 167, 1982–1988 (2001).
Seder, R.A., Paul, W.E., Davis, M.M. & Fazekas de St Groth, B. J. Exp. Med. 176, 1091–1098 (1992).
Moqbel, R. et al. J. Immunol. 155, 4939–4947 (1995).
Ying, S. et al. J. Immunol. 158, 3539–3544 (1997).
Brunner, T., Heusser, C.H. & Dahinden, C.A. J. Exp. Med. 177, 605–611 (1993).
Fort, M.M. et al. Immunity 15, 985–995 (2001).
Pesce, J. et al. J. Clin. Invest. 116, 2044–2055 (2006).
Liu, Y.J. et al. Annu. Rev. Immunol. 25, 193–219 (2007).
Rank, M.A. et al. J. Allergy Clin. Immunol. 116, 2044–2055 (2009).
Pulendran, B. et al. Proc. Natl. Acad. Sci. USA 96, 1036–1041 (1999).
Maldonado-Lopez, R. et al. J. Exp. Med. 189, 587–592 (1999).
Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. Nat. Immunol. 9, 310–318 (2008).
Jung, S. et al. Immunity 17, 211–220 (2002).
Lemos, M.P., Fan, L., Lo, D. & Laufer, T.M. J. Immunol. 171, 5077–5084 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wynn, T. Basophils trump dendritic cells as APCs for TH2 responses. Nat Immunol 10, 679–681 (2009). https://doi.org/10.1038/ni0709-679
Issue Date:
DOI: https://doi.org/10.1038/ni0709-679
This article is cited by
-
The role of β2 integrin in dendritic cell migration during infection
BMC Immunology (2021)
-
Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial
Journal of the International Society of Sports Nutrition (2018)
-
Shuang-Huang-Lian prevents basophilic granulocyte activation to suppress Th2 immunity
BMC Complementary and Alternative Medicine (2018)
-
The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test
Clinical and Translational Allergy (2016)
-
Trichuris muris: a model of gastrointestinal parasite infection
Seminars in Immunopathology (2012)