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Basophils trump dendritic cells as APCs for TH2 responses

Dendritic cells are best known as antigen-presenting cells that initiate adaptive immune responses. Three new papers suggest that basophils initiate allergen- and helminth-driven CD4+ T helper type 2 responses by functioning as antigen-presenting cells in draining lymph nodes.

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Figure 1: A new paradigm for the initiation of type 2 immunity.

Katie Vicari

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Wynn, T. Basophils trump dendritic cells as APCs for TH2 responses. Nat Immunol 10, 679–681 (2009). https://doi.org/10.1038/ni0709-679

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