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PTEN gives neutrophils direction

Nature Immunology volume 9, pages 716–718 (2008)Cite this article

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Neutrophils can respond to many chemotactic signals, but how these cells 'prioritize' such signals to react to invading pathogens has remained unclear. The phosphatase PTEN seems to be critical in directing the migration of neutrophils toward their end target in a complex milieu of competing signals.

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Figure 1: PTEN promotes the chemotaxis of neutrophils toward bacterial infection.

Katie Ris-Vicari

Change history

  • 21 July 2008

    In the version of this article initially published, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) is incorrectly identified as phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2). The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Daniel D. Billadeau is in the Department of Immunology and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. billadeau.daniel@mayo.edu,

    Daniel D Billadeau

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  1. Daniel D Billadeau
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Billadeau, D. PTEN gives neutrophils direction. Nat Immunol 9, 716–718 (2008). https://doi.org/10.1038/ni0708-716

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