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  • Historical Commentary
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Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff

Nature Immunology volume 9, pages 705–712 (2008)Cite this article

Abstract

One hundred years ago the birth of immunology was made official by the Nobel Prize award to Elie Metchnikoff and Paul Ehrlich. Metchnikoff discovered phagocytosis by macrophages and microphages as a critical host-defense mechanism and thus is considered the father of cellular innate immunity. Ehrlich described the side-chain theory of antibody formation and the mechanisms of how antibodies neutralize toxins and induce bacterial lysis with the help of complement and thus is considered one of the fathers of humoral adaptive immunity. Despite many discordant discussions in the initial phase after these discoveries, innate and adaptive responses are now known to be complementary partners in producing robust immunity.

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Figure 1
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Figure 5: Synergy between specific antibodies and nonspecific phagocytes in the uptake of meningococci by granulocytes.

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Acknowledgements

I thank M.L. Grossman for help in preparing this manuscript and D. Schad for preparing the artwork. Unless otherwise stated, all citations have been 'freely translated' into English by me and all cited papers are in my possession in original form or as copies.

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  1. Department of Immunology, Stefan H.E. Kaufmann is with the Max Planck Institute for Infection Biology, D-10117 Berlin, Germany. kaufmann@mpiib-berlin.mpg.des,

    Stefan H E Kaufmann

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Kaufmann, S. Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff. Nat Immunol 9, 705–712 (2008). https://doi.org/10.1038/ni0708-705

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