Cognate antigen triggers B cells to undergo antibody maturation and terminal differentiation into antibody-secreting plasma cells. The transcription factor IRF4, which is essential for early B cell development, is also influential at these later stages of B cell development and function.
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Fillatreau, S., Radbruch, A. IRF4 – a factor for class switching and antibody secretion. Nat Immunol 7, 704–706 (2006). https://doi.org/10.1038/ni0706-704
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DOI: https://doi.org/10.1038/ni0706-704
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