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IRF4 – a factor for class switching and antibody secretion

Nature Immunology volume 7, pages 704706 (2006) | Download Citation

Subjects

Cognate antigen triggers B cells to undergo antibody maturation and terminal differentiation into antibody-secreting plasma cells. The transcription factor IRF4, which is essential for early B cell development, is also influential at these later stages of B cell development and function.

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Affiliations

  1. Simon Fillatreau and Andreas Radbruch are with Deutsches Rheuma-Forschungszentrum, Berlin 10117, Germany. radbruch@drfz.de

    • Simon Fillatreau
    •  & Andreas Radbruch

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DOI

https://doi.org/10.1038/ni0706-704

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