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Gene expression microarrays: glimpses of the immunological genome

Nature Immunology volume 7, pages 686–691 (2006)Cite this article

Successful microarray experimentation can generate enormous amounts of data, potentially very rich but also very unwieldy. Bold outlooks and new methods for data analysis and presentation should yield additional insight into the complexities of the immune system.

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Figure 1: Differentiating cells by microarray analysis.
Figure 2: Gene expression networks in the immune system.
Figure 3: Complex data representations in art and immunogenomics.

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Acknowledgements

We thank D. Laidlaw, J.J. Collins and D. Koller for discussions; E. Hyatt, Q.M. Pham, G. Losyev, R. Saccone and J. Johnson for assistance with mice, cell sorting and microarray processing; and the S+ Listserv members for advice. Supported by the National Institutes of Health (AR046580, AI51530, AI52343, DK60027, DK59658 to C.B. and D.M.) and the William T. Young Chair.

Author information

Author notes

  1. Laurent Poirot & Ann Herman

    Present address: Genomics Institute of the Novartis Research Foundation, San Diego, 92121, California, USA

  2. Silvia Zucchelli

    Present address: SISSA-LNM, Area Science Park, Basovizza, 34012, Trieste, Italy

  3. Michael Matos

    Present address: Wolfeboro Pediatrics, Wolfeboro, 03894, New Hampshire, USA

  4. Ananda Goldrath

    Present address: Division of Biology, University of San Diego, La Jolla, 92093, California, USA

  5. Linh Nguyen

    Present address: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada

  6. Tetsuya Yamagata

    Present address: Department of Hematology, Dokkyo University School of Medicine, Tochigi-Ken, Japan

Authors and Affiliations

  1. Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women's Hospital and Harvard Medical School, Boston, 02215, Massachusetts, USA

    Gordon Hyatt, Rachel Melamed, Richard Park, Reuben Seguritan, Catherine Laplace, Laurent Poirot, Silvia Zucchelli, Reinhard Obst, Michael Matos, Emily Venanzi, Ananda Goldrath, Linh Nguyen, John Luckey, Tetsuya Yamagata, Ann Herman, Jonathan Jacobs, Diane Mathis & Christophe Benoist

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Hyatt, G., Melamed, R., Park, R. et al. Gene expression microarrays: glimpses of the immunological genome. Nat Immunol 7, 686–691 (2006). https://doi.org/10.1038/ni0706-686

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