Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

RIGging an antiviral defense—it's in the CARDs

Nature Immunology volume 5, pages699–701(2004)Cite this article

How do cells fend off intracellular viruses that slip in below extracellular defensive 'radar screens'? The identification of a cytoplasmic RNA helicase that signals through CARD interactions links viral detection to the interferon-β induction pathway.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

Figure 1: Signaling pathways leading to IFN-β induction.

K.R.

References

  1. 1

    Levy, D.E., Marié, I. & Prakash, A. Curr. Opin. Immunol. 15, 52–58 (2003).

    CAS  Article  Google Scholar 

  2. 2

    Yoneyama, M. et al. EMBO J. 17, 1087–1095 (1998).

    CAS  Article  Google Scholar 

  3. 3

    Yoneyama, M. et al. Nat. Immunol. 5, 730–737 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Yang, Y.L. et al. EMBO J. 14, 6095–6106 (1995).

    CAS  Article  Google Scholar 

  5. 5

    Honda, K. et al. Proc. Natl. Acad. Sci. USA 100, 10872–10877 (2003).

    CAS  Article  Google Scholar 

  6. 6

    Smith, A.E. & Helenius, A. Science 304, 237–242 (2004).

    CAS  Article  Google Scholar 

  7. 7

    tenOever, B.R., Servant, M.J., Grandvaux, N., Lin, R. & Hiscott, J. J. Virol. 76, 3659–3669 (2002).

    CAS  Article  Google Scholar 

  8. 8

    Hofmann, K., Bucher, P. & Tschopp, J. Trends Biochem. Sci 22, 155–156 (1997).

    CAS  Article  Google Scholar 

  9. 9

    Kobayashi, K. et al. Nature 416, 194–199 (2002).

    CAS  Article  Google Scholar 

  10. 10

    Fitzgerald, K.A. et al. Nat. Immunol. 4, 491–496 (2003).

    CAS  Article  Google Scholar 

  11. 11

    Sharma, S. et al. Science 300, 1148–1151 (2003).

    CAS  Article  Google Scholar 

  12. 12

    Fairman, M.E. et al. Science 304, 730–734 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. Departments of Pathology and Microbiology

    David E Levy & Isabelle J Marié

  2. Department of Pathology, New York University School of Medicine, New York, 10016, New York, USA

    David E Levy & Isabelle J Marié

Authors
  1. David E Levy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabelle J Marié
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Levy, D., Marié, I. RIGging an antiviral defense—it's in the CARDs. Nat Immunol 5, 699–701 (2004). https://doi.org/10.1038/ni0704-699

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing