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RIGging an antiviral defense—it's in the CARDs

How do cells fend off intracellular viruses that slip in below extracellular defensive 'radar screens'? The identification of a cytoplasmic RNA helicase that signals through CARD interactions links viral detection to the interferon-β induction pathway.

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Figure 1: Signaling pathways leading to IFN-β induction.

K.R.

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Levy, D., Marié, I. RIGging an antiviral defense—it's in the CARDs. Nat Immunol 5, 699–701 (2004). https://doi.org/10.1038/ni0704-699

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