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ICOS costimulation: it's not just for TH2 cells anymore

Nature Immunology volume 2, pages 573–574 (2001)Cite this article

A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.

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Figure 1: “Strength of signal” models for ICOS-mediated costimulation.

Bob Crimi

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Author information

Authors and Affiliations

  1. Department of Medicine, Section of Pulmonary and Critical Care Medicine,

    Anne I. Sperling

  2. Immunology, University of Chicago, Chicago, IL 60637, USA

    Anne I. Sperling

  3. A. W. and Mary Margaret Clausen Professor, Department of Medicine, UCSF Diabetes Center, University of California, San Francisco, San Francisco, 94143, CA, USA

    Jeffrey A. Bluestone

Authors
  1. Anne I. Sperling
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  2. Jeffrey A. Bluestone
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Sperling, A., Bluestone, J. ICOS costimulation: it's not just for TH2 cells anymore. Nat Immunol 2, 573–574 (2001). https://doi.org/10.1038/89709

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