Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.
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Rathinam, V., Sharma, S. & Fitzgerald, K. Catenin' on to nucleic acid sensing. Nat Immunol 11, 466–468 (2010). https://doi.org/10.1038/ni0610-466
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DOI: https://doi.org/10.1038/ni0610-466
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