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IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation

Nature Immunology volume 10, pages 568570 (2009) | Download Citation

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T helper type 1 cells (TH1 cells) serve a dominant function in T cell–mediated colitis. New work reports that interleukin 17A, an effector cytokine required for the development of autoimmune tissue inflammation, directly inhibits TH1 development by suppressing the expression of key TH1-associated genes and therefore regulates TH1 cell–mediated colitis.

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Affiliations

  1. Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.  vkuchroo@rics.bwh.harvard.edu

    • Amit Awasthi
    •  & Vijay K Kuchroo

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DOI

https://doi.org/10.1038/ni0609-568

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