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From IFN to TNF: a journey into realms of lore

Jan Vilcek relates how his work helped to identify some of the pleiotropic actions of tumor necrosis factor and contributed to the development of infliximab, the first medically useful tumor necrosis factor antagonist.

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References

  1. 1

    Vilcek, J. My fifty years with interferon. J. Interferon Cytokine Res. 27, 535–542 (2007).

    CAS  Article  Google Scholar 

  2. 2

    Vilcek, J. An interferon-like substance released from tickborne encephalitis virus-infected chick embryo fibroblast cells. Nature 187, 73–74 (1960).

    CAS  Article  Google Scholar 

  3. 3

    Vilcek, J. Interferon research BC (before cloning). Curr. Top. Microbiol. Immunol. 316, 9–22 (2007).

    CAS  PubMed  Google Scholar 

  4. 4

    Stone-Wolff, D.S. et al. Interrelationships of human interferon-γ with lymphotoxin and monocyte cytotoxin. J. Exp. Med. 159, 828–843 (1984).

    CAS  Article  Google Scholar 

  5. 5

    Carswell, E.A. et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl. Acad. Sci. USA 72, 3666–3670 (1975).

    CAS  Article  Google Scholar 

  6. 6

    Aggarwal, B.B. et al. Human tumor necrosis factor. Production, purification, and characterization. J. Biol. Chem. 260, 2345–2354 (1985).

    CAS  PubMed  Google Scholar 

  7. 7

    Nedwin, G.E. et al. Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res. 13, 6361–6373 (1985).

    CAS  Article  Google Scholar 

  8. 8

    Beutler, B. et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316, 552–554 (1985).

    CAS  Article  Google Scholar 

  9. 9

    Tsujimoto, M., Yip, Y.K. & Vilcek, J. Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells. Proc. Natl. Acad. Sci. USA 82, 7626–7630 (1985).

    CAS  Article  Google Scholar 

  10. 10

    Vilcek, J. et al. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J. Exp. Med. 163, 632–643 (1986).

    CAS  Article  Google Scholar 

  11. 11

    Lin, J.-X. & Vilcek, J. Tumor necrosis factor and interleukin-1 cause a rapid and transient stimulation of c-fos and c-myc mRNA levels in human fibroblasts. J. Biol. Chem. 262, 11908–11911 (1987).

    CAS  PubMed  Google Scholar 

  12. 12

    Kohase, M., Henriksen-DeStefano, D., May, L.T., Vilcek, J. & Sehgal, P.B. Induction of β2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell 45, 659–666 (1986).

    CAS  Article  Google Scholar 

  13. 13

    Reis, L.F.L., Lee, T.H. & Vilcek, J. Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human fibroblasts. J. Biol. Chem. 264, 16351–16354 (1989).

    CAS  PubMed  Google Scholar 

  14. 14

    Lee, T.H., Lee, G.W., Ziff, E.B. & Vilcek, J. Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts. Mol. Cell. Biol. 10, 1982–1988 (1990).

    CAS  Article  Google Scholar 

  15. 15

    Lee, T.H., Wisniewski, H.-G. & Vilcek, J. A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J. Cell Biol. 116, 545–557 (1992).

    CAS  Article  Google Scholar 

  16. 16

    Wisniewski, H.-G., Burgess, W.H., Oppenheim, J.D. & Vilcek, J. TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-α-inhibitor. Biochemistry 33, 7423–7429 (1994).

    CAS  Article  Google Scholar 

  17. 17

    Lee, G.W., Lee, T.H. & Vilcek, J. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J. Immunol. 150, 1804–1812 (1993).

    CAS  PubMed  Google Scholar 

  18. 18

    Wisniewski, H.G. & Vilcek, J. Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14. Cytokine Growth Factor Rev. 15, 129–146 (2004).

    CAS  Article  Google Scholar 

  19. 19

    Garlanda, C., Bottazzi, B., Bastone, A. & Mantovani, A. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu. Rev. Immunol. 23, 337–366 (2005).

    CAS  Article  Google Scholar 

  20. 20

    Beutler, B., Milsark, I.W. & Cerami, A.C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229, 869–871 (1985).

    CAS  Article  Google Scholar 

  21. 21

    Knight, D.M. et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol. Immunol. 30, 1443–1453 (1993).

    CAS  Article  Google Scholar 

  22. 22

    Siegel, S.A. et al. The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo. Cytokine 7, 15–25 (1995).

    CAS  Article  Google Scholar 

  23. 23

    Elliott, M.J. et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum. 36, 1681–1690 (1993).

    CAS  Article  Google Scholar 

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Vilcek, J. From IFN to TNF: a journey into realms of lore. Nat Immunol 10, 555–557 (2009). https://doi.org/10.1038/ni0609-555

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