The T cell receptor (TCR) is functionally coupled to a constellation of ten immunoreceptor tyrosine–based activation motifs (ITAMs). A new study suggests that this large number of ITAMs is mandatory for preventing autoimmunity.
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Malissen, B. CD3 ITAMs count!. Nat Immunol 9, 583–584 (2008). https://doi.org/10.1038/ni0608-583
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