Harald von Boehmer describes how he used mice transgenic for T cell receptor αβ to identify T cell receptor–dependent cellular selection and lineage commitment as mechanisms responsible for generating an effective and self-tolerant adaptive immune system.
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Acknowledgements
I thank my collaborators (listed as authors in the references); the staff of the Basel Institute for Immunology, who contributed to its unique status in science; and my wife Monica for understanding the ups and downs of a researcher's life.
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von Boehmer, H. Positive and negative selection in Basel. Nat Immunol 9, 571–573 (2008). https://doi.org/10.1038/ni0608-571
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DOI: https://doi.org/10.1038/ni0608-571
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