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Why study the evolution of immunity?

Investigations of immune recognition in nonmammalian species provide new insights into the evolution of immunity and the inner workings of the mammalian immune system. Very diverse mechanisms are used by different multicellular organisms to recognize and cope with the rapidly evolving microbial world.

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Figure 1: Present ideas of immune diversity in alternative model systems.

M. Sexton


  1. 1

    Metchnikoff, I. Lectures on the Comparative Pathology of Inflammation Delivered at the Pasteur Institute in 1891 (Dover, New York, 1891).

    Google Scholar 

  2. 2

    Cooper, M.D., Peterson, R.D.A. & Good, R.A. Nature 205, 143–146 (1965).

    CAS  Article  Google Scholar 

  3. 3

    Reynaud, C.-A., Anquez, V., Grimal, H. & Weill, J.-C. Cell 48, 379–388 (1987).

    CAS  Article  Google Scholar 

  4. 4

    Hoffmann, J.A. Nature 426, 33–38 (2003).

    CAS  Article  Google Scholar 

  5. 5

    Hoffmann, J.A., Kafatos, F.C., Janeway, C.A. & Ezekowitz, R.A. Science 284, 1313–1318 (1999).

    CAS  Article  Google Scholar 

  6. 6

    Iwasaki, A. & Medzhitov, R. Nat. Immunol. 5, 987–995 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Litman, G.W., Cannon, J.P. & Dishaw, L.J. Nat. Rev. Immunol. 5, 866–879 (2005).

    CAS  Article  Google Scholar 

  8. 8

    Pancer, Z. et al. Nature 430, 174–180 (2004).

    CAS  Article  Google Scholar 

  9. 9

    Zhang, S.-M., Adema, C.M., Kepler, T.B. & Loker, E.S. Science 305, 251–254 (2004).

    CAS  Article  Google Scholar 

  10. 10

    Watson, F.L. et al. Science 309, 1874–1878 (2005).

    CAS  Article  Google Scholar 

  11. 11

    Sadd, B.M. & Schmid-Hempel, P. Curr. Biol. 16, 1206–1210 (2006).

    CAS  Article  Google Scholar 

  12. 12

    Laird, D.J., De Tomaso, A.W. & Weissman, I.L. Cell 123, 1351–1360 (2005).

    CAS  Article  Google Scholar 

  13. 13

    Pancer, Z. & Cooper, M.D. Annu. Rev. Immunol. 24, 497–518 (2006).

    CAS  Article  Google Scholar 

  14. 14

    McFall-Ngai, M. Nature 445, 153 (2007).

    CAS  Article  Google Scholar 

  15. 15

    Fugmann, S.D., Messier, D., Novack, L.A., Cameron, R.A. & Rast, J.P. Proc. Natl. Acad. Sci. USA 103, 3728–3733 (2006).

    CAS  Article  Google Scholar 

  16. 16

    Rast, J.P., Smith, L.C., Loza-Coll, M., Hibino, T. & Litman, G.W. Science 314, 952–956 (2006).

    CAS  Article  Google Scholar 

  17. 17

    Davidson, E.H. & Erwin, D.H. Science 311, 796–800 (2006).

    CAS  Article  Google Scholar 

  18. 18

    Langenau, D.M. & Zon, L.I. Nat. Rev. Immunol. 5, 307–317 (2005).

    CAS  Article  Google Scholar 

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Litman, G., Cooper, M. Why study the evolution of immunity?. Nat Immunol 8, 547–548 (2007).

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