To prevent RNA virus–dependent tissue damage caused by interferon-regulatory factor 3 (IRF3)–induced type I interferons, proteasome-dependent destruction of IRF3 is orchestrated by the cytoplasmic prolyl isomerase Pin1.
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References
Kawai, T. & Akira, S. Nat. Immunol. 7, 131–137 (2006).
Thanos, D. & Maniatis, T. Cell 83, 1091–1100 (1995).
Rothenfusser, S. et al. J. Immunol. 175, 5260–5268 (2005).
Yoneyama, M. et al. J. Immunol. 175, 2851–2858 (2005).
Saitoh, T. et al. Nat. Immunol. 7, 598–605 (2006).
Fitzgerald, K.A. et al. Nat. Immunol. 4, 491–496 (2003).
Sharma, S. et al. Science 300, 1148–1151 (2003).
Lin, R., Heylbroeck, C., Pitha, P.M. & Hiscott, J. Mol. Cell. Biol. 18, 2986–2996 (1998).
Wulf, G., Finn, G., Suizu, F. & Lu, K.P. Nat. Cell Biol. 7, 435–441 (2005).
Obata, Y. et al. J. Biol. Chem. 280, 18355–18360 (2005).
Wulf, G.M. et al. EMBO J. 20, 3459–3472 (2001).
Ryo, A. et al. Mol. Cell 12, 1413–1426 (2003).
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Goutagny, N., Severa, M. & Fitzgerald, K. Pin-ning down immune responses to RNA viruses. Nat Immunol 7, 555–557 (2006). https://doi.org/10.1038/ni0606-555
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DOI: https://doi.org/10.1038/ni0606-555
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