Cutting into innate immunity

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Human caspase-12, unlike that found in the mouse, is not involved in apoptosis and thus its physiological function is unclear. However, a unique polymorphism of human caspase-12 has demonstrated its importance in innate immunity.

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Figure 1: Innate immune response signaling and a hypothetical mechanism of feedback inhibition by caspase-12.

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Winoto, A. Cutting into innate immunity. Nat Immunol 5, 563–564 (2004) doi:10.1038/ni0604-563

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