V(D)J recombinational accessibility—heading in the opposite direction?

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The assembly of antigen receptor genes in developing lymphocytes through V(D)J recombination is regulated through a mostly undefined but broadly relevant process referred to as 'accessibility'. New findings raise the possibility that wide-ranging, antisense transcription through unrearranged antigen receptor loci could be involved in modulating recombinational accessibility.

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Figure 1: Developmental regulation of the Igh locus transcription and rearrangement.

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Giallourakis, C., Alt, F. & Bassing, C. V(D)J recombinational accessibility—heading in the opposite direction?. Nat Immunol 5, 561–562 (2004) doi:10.1038/ni0604-561

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