The mechanisms that regulate self-renewal of hematopoietic stem cells have remained elusive. Recent papers in Nature point to an important role of the Wnt–β-catenin signaling pathway in promoting this process.
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References
Ivanova, N.B. et al. Science 298, 601–604 (2002).
Ramalho-Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R.C. & Melton, D.A. Science 298, 597–600 (2002).
Miller, C.L. & Eaves, C.J. Proc. Natl. Acad. Sci. USA 94, 13648–13653 (1997).
Yonemura, Y., Ku, H., Hirayama, F., Souza, L.M. & Ogawa, M. Proc. Natl. Acad. Sci. USA 93, 4040–4044 (1996).
Ema, H., Takano, H., Sudo, K. & Nakauchi, H. J. Exp. Med. 192, 1281–1288 (2000).
Audet, J., Miller, C.L., Eaves, C.J. & Piret, J.M. Biotechnol. Bioeng. 80, 393–404 (2002).
Reya, T. et al. Nature advance online publication, 27 April 2003 (doi:10.1038/nature01593).
Willert, K. et al. Nature advance online publication, 27 April 2003 (doi:10.1038/nature01611).
Szilvassy, S.J., Ragland, P.L., Miller, C.L. & Eaves, C.J. Exp. Hematol. 31, 331–338 (2003).
Iscove, N. et al. Exp. Hematol. 30 (Suppl 1), 38 (2002).
Sauvageau, G. et al. Proc. Natl. Acad. Sci. USA 91, 12223–12227 (1994).
Sauvageau, G. et al. Genes Dev. 9, 1753–1765 (1995).
Antonchuk, J., Sauvageau, G. & Humphries, R.K. Cell 109, 39–45 (2002).
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Eaves, C. Manipulating hematopoietic stem cell amplification with Wnt. Nat Immunol 4, 511–512 (2003). https://doi.org/10.1038/ni0603-511
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DOI: https://doi.org/10.1038/ni0603-511
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