Genetic ablation experiments have shown that Vav is critical for TCR signaling. Evidence is now emerging that the Vav family of signaling molecules play a critical role in antigen receptor signaling in B cells as well as in T cells.
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DeFranco, A. Vav and the B cell signalosome. Nat Immunol 2, 482–484 (2001). https://doi.org/10.1038/88669
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DOI: https://doi.org/10.1038/88669
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