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HIV-1 and pattern-recognition receptors: a marriage of convenience

Nature Immunology volume 11, pages 363–365 (2010)Cite this article

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Dendritic cells can internalize and degrade invading pathogens in phagosomes, yet some HIV-1 particles can evade this degradation process and productively infect dendritic cells. New data show that HIV-1 replication is triggered by signal-transduction events through Toll-like receptor 8 and DC-SIGN.

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Figure 1: Productive infection of DCs requires signal-transduction events mediated by TLR8 and DC-SIGN.

Michel Ouellet

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Authors and Affiliations

  1. Michel J. Tremblay is in the Centre de Recherche en Infectiologie, Centre Hospitalier de l'Université Laval, Québec, Canada.,

    Michel J Tremblay

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  1. Michel J Tremblay
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Correspondence to Michel J Tremblay.

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The author declares no competing financial interests.

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Tremblay, M. HIV-1 and pattern-recognition receptors: a marriage of convenience. Nat Immunol 11, 363–365 (2010). https://doi.org/10.1038/ni0510-363

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