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Trawling for treasure: tales of T-bet

Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a transcription factor that is a 'master regulator' of commitment to the T helper type 1 lineage.

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Acknowledgements

I thank the graduate students and postdoctoral fellows I have worked with over the past two decades and the US National Institutes of Health for its continued support since 1982.

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Glimcher, L. Trawling for treasure: tales of T-bet. Nat Immunol 8, 448–450 (2007). https://doi.org/10.1038/ni0507-448

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