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Blimp-1 over Budapest

Blimp-1 is a transcription factor that affects the expression of hundreds of genes in lymphocytes. Recent work confirmed its role in the maturation of B cells into immunoglobulin-secreting plasmablasts, as well as in the control of T cell homeostasis and tolerance. What follows is a short history of how Blimp-1 was discovered.

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Acknowledgements

I thank everyone in my group who has ever worked on Blimp-1, especially, of course, Alex Turner, David Mack, Eric Messika, Ashley Chi and Roger Sciammis for their valiant efforts. This work was supported by grants from the NIH and the Howard Hughes Medical Institute.

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Davis, M. Blimp-1 over Budapest. Nat Immunol 8, 445–447 (2007). https://doi.org/10.1038/ni0507-445

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