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Dissecting worm immunity

The function of the mammalian TIR domain adaptor protein SARM is unclear. In Caenorhabditis elegans, however, the homolog of SARM controls the induction of peptides involved in innate immunity.

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Figure 1: The nematode C. elegans induces defense peptides in response to pathogens.

Nathalie Pujol

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Hodgkin, J. Dissecting worm immunity. Nat Immunol 5, 471–472 (2004). https://doi.org/10.1038/ni0504-471

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