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Linking Toll-like receptors to IFN-α/β expression

Nature Immunology volume 4, pages 432–433 (2003)Cite this article

Many infectious agents elicit a type I interferon response, but the molecular details that lead to IFN-α/β expression have remained obscure. New details are emerging about how specific TLRs signal IFN-α/β expression.

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Figure 1: TLR signaling pathways leading to the activation of IRF3 and NF-κB.

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  1. Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar St., CAB S660, New Haven, 06520, CT

    Gregory M. Barton & Ruslan Medzhitov

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  1. Gregory M. Barton
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  2. Ruslan Medzhitov
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Correspondence to Ruslan Medzhitov.

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Barton, G., Medzhitov, R. Linking Toll-like receptors to IFN-α/β expression. Nat Immunol 4, 432–433 (2003). https://doi.org/10.1038/ni0503-432

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