The pTα cytoplasmic chain was initially thought to be dispensable for T cell development. A reanalysis of the pTα cytoplasmic tail now shows this domain plays a critical role in pre-TCR signaling.
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Killeen, N. A new spin on an unusual tail. Nat Immunol 3, 419–421 (2002). https://doi.org/10.1038/ni0502-419
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DOI: https://doi.org/10.1038/ni0502-419
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