HIV-1 Nef: negative effector of Fas?

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The disappearance of CD4+ T cells during an HIV infection sets the stage for the characteristic immunodeficiency. But how do the virally infected cells protect themselves long enough to manufacture more HIV virions? A recent paper in Nature suggests that Nef may be part of the answer.

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Figure 1: The inhibitory effect of HIV-1 Nef in Fas- or TNFR-induced apoptosis.

Bob Crimi

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