Helper T cell differentiation: a role for SAP?

Differentiation of periperal T cells into TH1 and TH2 subsets is a crucial part of a normal immune response. Evidence is emerging that a signaling pathway involving the SAP molecule may play an important role in this differentiation process.

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Figure 1: Effect of SAP expression on TH differentiation.

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Fields, P., Flavell, R. Helper T cell differentiation: a role for SAP?. Nat Immunol 2, 382–384 (2001). https://doi.org/10.1038/87679

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