The CD8 response on autopilot

Activation, proliferation and differentiation of CD8+ cytotoxic T cells must be carefully regulated. New evidence suggests that antigen and costimulation may be enough to trigger the program.

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Figure 1: A brief encounter with MHC–peptide antigen on an APC is sufficient for naïve CD8+ T cells to set in motion a program of proliferation and differentiation.

Bob Crimi

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Bevan, M., Fink, P. The CD8 response on autopilot. Nat Immunol 2, 381–382 (2001). https://doi.org/10.1038/87676

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