To live and let die

Adjuvants and inflammation inhibit TCR ligation-induced apoptosis of T cells. Bcl-3 may enhance the increased T cell survival by positive regulation of NF-κB transcription factors.

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Figure 1: Intercellular signaling mechanisms that promote survival of antigen-stimulated T cells.

Bob Crimi

Figure 2: Growth factors (for example, IL-4, IL-7 and IL-9) also induce Bcl-3 expression in T cells, which leads to increased expression of NF-κB prosurvival target genes.

Bob Crimi

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Gerondakis, S., Strasser, A. To live and let die. Nat Immunol 2, 377–379 (2001). https://doi.org/10.1038/87669

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