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To live and let die

Nature Immunology volume 2, pages 377–379 (2001)Cite this article

Adjuvants and inflammation inhibit TCR ligation-induced apoptosis of T cells. Bcl-3 may enhance the increased T cell survival by positive regulation of NF-κB transcription factors.

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Figure 1: Intercellular signaling mechanisms that promote survival of antigen-stimulated T cells.

Bob Crimi

Figure 2: Growth factors (for example, IL-4, IL-7 and IL-9) also induce Bcl-3 expression in T cells, which leads to increased expression of NF-κB prosurvival target genes.

Bob Crimi

References

  1. Newton, K. & Strasser, A. Adv. Immunol. 76, 179–226 (2001).

    Article  Google Scholar 

  2. Mitchell, T. C. et al. Nature Immunol. 2, 397–402 (2001).

    Article  CAS  Google Scholar 

  3. Bouillet, P. et al. Science 286, 1735–1738 (1999).

    Article  CAS  Google Scholar 

  4. Strasser, A., Harris, A. W., Huang, D. C. S., Krammer, P. H. & Cory, S. EMBO J. 14, 6136–6147 (1995).

    Article  CAS  Google Scholar 

  5. Gugasyan, R. et al. Immunol. Rev. 176, 134–140 (2000).

    Article  CAS  Google Scholar 

  6. Richard, M., Louahed, J., Demoulin, J. B. & Renauld, J. C. Blood 93, 4318–4327 (1999).

    CAS  PubMed  Google Scholar 

  7. Rebollo, A. et al. Mol. Cell Biol. 20, 3407–3426 (2000).

    Article  CAS  Google Scholar 

  8. Franzoso, G. et al. Immunity 6, 479–490 (1997).

    Article  CAS  Google Scholar 

  9. Schwarz, E. M., Krimpenfort, P., Berns, A. & Verma, I. M. Genes Dev. 11, 187–197 (1997).

    Article  CAS  Google Scholar 

  10. Franzoso, G. et al. Nature 359, 339–342 (1992).

    Article  CAS  Google Scholar 

  11. Kerr, L. D. et al. Genes Dev. 6, 2352–2363 (1992).

    Article  CAS  Google Scholar 

  12. Ong, S. T. et al. Oncogene 16, 2333–2343 (1998).

    Article  CAS  Google Scholar 

  13. Strasser, A., Harris, A. W., Bath, M. L. & Cory, S. Nature 348, 331–333 (1990).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Australia

    Steve Gerondakis & Andreas Strasser

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  1. Steve Gerondakis
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  2. Andreas Strasser
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Gerondakis, S., Strasser, A. To live and let die. Nat Immunol 2, 377–379 (2001). https://doi.org/10.1038/87669

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