Developing intestinal fortitude

The development and function of TCRαβ+CD8αα+ intraepithelial lymphocytes remain poorly understood. These cells are now shown to require transforming growth factor-β for development and proper expression of characteristic surface homodimers of CD8α.

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Figure 1: Selective blockade of the development of TCRαβ+CD8αα+ IELs in TGFβ-deficient mice.

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Correspondence to Dietmar J Kappes.

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Kappes, D. Developing intestinal fortitude. Nat Immunol 12, 281–282 (2011). https://doi.org/10.1038/ni0411-281

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