Gene-environment interactions in chronic inflammatory disease

Chronic inflammatory diseases represent a major challenge for both clinical research and patient care, and evidence indicates that these disorders develop as a result of complex gene-environment interactions. Better understanding of their cause-and-effect relationship is the basis for emerging proposals for therapy and prevention.

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Figure 1: A new paradigm for the development of chronic inflammation.
Figure 2: Metabolic and immune-mediated pathologies with inflammatory processes in various target organs as the key driver of disease initiation and/or perpetuation.

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Correspondence to Harald Renz.

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Renz, H., von Mutius, E., Brandtzaeg, P. et al. Gene-environment interactions in chronic inflammatory disease. Nat Immunol 12, 273–277 (2011). https://doi.org/10.1038/ni0411-273

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