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Location, location, location: identifying the neighborhoods of LPS signaling

Nature Immunology volume 9, pages 343–345 (2008)Cite this article

TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitov and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.

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Figure 1: Sequential engagement of MyD88 and TRIF adaptors by TLR4.

Kim Caesar

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  1. Colin Watts is in the Division of Cell Biology and Immunology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. c.watts@dundee.ac.uk,

    Colin Watts

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Watts, C. Location, location, location: identifying the neighborhoods of LPS signaling. Nat Immunol 9, 343–345 (2008). https://doi.org/10.1038/ni0408-343

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