Abstract
As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Traub, E. Epidemiology of lymphocytic choriomeningitis in a mouse stock observed for four years. J. Exp. Med. 69, 801–817 (1939).
Burnet, F.M. & Fenner, F. The Production of Antibodies (ed. Burnet, F.M.) 1–142 (MacMillan, New York, 1949).
Oldstone, M.B.A. & Dixon, F.J. Lymphocytic choriomeningitis: production of anti-LCM antibody by 'tolerant' LCM-infected mice. Science 158, 1193–1194 (1967).
Oldstone, M.B.A., Aoki, T. & Dixon, F.J. The antibody response of mice to murine leukemia virus in spontaneous infection. Absence of classical immunologic tolerance. Proc. Natl. Acad. Sci. USA 69, 134–138 (1972).
Zinkernagel, R.M. Lymphocytic choriomeningitis virus and immunology. Curr. Top. Microbiol. Immunol. 263, 1–6 (2002).
Oldstone, M.B.A., Habel, K. & Dixon, F.J. The pathogenesis of cellular injury associated with persistent LCM viral infection. Fed. Proc. 28, 429–432 (1969).
Lundstedt, C. Interaction between antigenically different cells: virus-induced cytotoxicity by immune lymphoid cells in vitro. Acta Pathol. Microbiol. Scand. 75, 139–152 (1969).
Cole, G.A., Nathanson, N. & Prendergast, R.A. Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. Nature 238, 335–337 (1972).
Zinkernagel, R.M. & Doherty, P.C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248, 701–702 (1974).
Ahmed, R. & Gray, D. Immunological memory and protective immunity: Understanding their relation. Science 272, 54–60 (1996).
Homann, D., Teyton, L. & Oldstone, M.B.A. Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat. Med. 7, 913–919 (2001).
Oldstone, M.B.A., Blount, P., Southern, P.J. & Lampert, P.W. Cytoimmunotherapy for persistent virus infection: Unique clearance pattern from the central nervous system. Nature 321, 239–243 (1986).
Volkert, M. & Larsen, J.H. Studies on immunological tolerance to LCM virus. 6. Immunity conferred on tolerant mice by immune sera and by grafts of homologous lymphoid cells. Acta Pathol. Microbiol. Scand. 63, 172–180 (1965).
Berger, D.P., Homann, D. & Oldstone, M.B.A. Defining parameters for successful immunocytotherapy of persistent viral infection. Virology 266, 257–263 (2000).
Oldstone, M.B.A. Cytotoxic T-lymphocytes in human viral and malaria infections. Curr. Topics Microbiol. Immunol. 189, 1–186 (1994).
Ahmed, R., Salmi, A., Butler, L.D., Chiller, J.M. & Oldstone, M.B.A. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160, 521–540 (1984).
Ahmed, R. & Oldstone, M.B.A. Organ-specific selection of viral variants during chronic infection. J. Exp. Med. 167, 1719–1724 (1988).
Salvato, M., Shimomaye, E., Southern, P. & Oldstone, M.B.A. Virus-lymphocyte interactions. IV. Molecular characterization of LCMV Armstrong (CTL+) small genomic segment and that of its variant, Clone 13 (CTL-). Virology 164, 517–522 (1988).
Salvato, M., Borrow, P., Shimomaye, E. & Oldstone, M.B.A. Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence. J. Virol. 65, 1863–1869 (1991).
Sevilla, N. et al. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J. Exp. Med. 192, 1249–1260 (2000).
Dockter, J., Evans, C.F., Tishon, A. & Oldstone, M.B.A. Competitive selection in vivo by a cell for one variant over another: implications for RNA virus quasispecies in vivo. J. Virol. 70, 1799–1803 (1996).
Cao, W. et al. Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science 282, 2079–2081 (1998).
Kunz, S., Sevilla, N., McGavern, D.B., Campbell, K.P. & Oldstone, M.B.A. Molecular analysis of the interaction of LCMV with its cellular receptor α-dystroglycan. J. Cell Biol. 155, 301–310 (2001).
Sevilla, N., McGavern, D.B., Teng, C., Kunz, S. & Oldstone, M.B.A. Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion. J. Clin. Invest. 113, 737–745 (2004).
Moskophidis, D., Lechner, F., Pircher, H. & Zinkernagel, R.M. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362, 758–761 (1993).
Zajac, A.J. et al. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188, 2205–2213 (1998).
Brooks, D.G., McGavern, D.B. & Oldstone, M.B.A. Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. J. Clin. Invest. 116, 1675–1685 (2006).
Brooks, D.G. et al. Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 12, 1301–1309 (2006).
Barber, D.L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682–687 (2006).
Day, C.L. et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443, 350–354 (2006).
Trautmann, L. et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat. Med. 12, 1198–1201 (2006).
Petrovas, C. et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J. Exp. Med. 203, 2281–2292 (2006).
Ejrnaes, M. et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 203, 2461–2472 (2006).
Acknowledgements
Supported by USPHS (AI009484, AI045927 and AI055540). This is publication number 18587 from The Scripps Research Institute.
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Oldstone, M. A suspenseful game of 'hide and seek' between virus and host. Nat Immunol 8, 325–327 (2007). https://doi.org/10.1038/ni0407-325
Issue Date:
DOI: https://doi.org/10.1038/ni0407-325
This article is cited by
-
Structure-function relationship of the mammarenavirus envelope glycoprotein
Virologica Sinica (2016)
-
Cross-Reactive Antibodies to Target Proteins are Dependent upon Oligomannose Glycosylated Epitopes in HTLV-1 Associated Neurological Disease
Journal of Clinical Immunology (2012)
-
Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases
Nature Immunology (2007)