Shh! Shh! It's, oh, so quiet

The regulated expression of Rag genes in lymphocytes ensures the expression of a single antigen receptor on the lymphocyte surface. It now seems that a complex 'ballet' of activating and silencing elements controls the precise timing of Rag expression in thymocytes.

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Figure 1: How to silence a gene (or not).

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Kioussis, D. Shh! Shh! It's, oh, so quiet. Nat Immunol 5, 353–354 (2004). https://doi.org/10.1038/ni0404-353

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