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The stressful road to antibody secretion

Nature Immunology volume 4, pages 310–311 (2003)Cite this article

Terminal B cell differentiation requires a massive increase in the biosynthetic capacity to synthesize antibodies in response to infection. New data shows the ER stress response activates and commits B cells to this robust metabolic state.

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Figure 1: Components of the mammalian UPR pathway and their role in plasma cell differentiation.

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Authors and Affiliations

  1. Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA

    Yanjun Ma & Linda M. Hendershot

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  1. Yanjun Ma
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  2. Linda M. Hendershot
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Correspondence to Linda M. Hendershot.

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Ma, Y., Hendershot, L. The stressful road to antibody secretion. Nat Immunol 4, 310–311 (2003). https://doi.org/10.1038/ni0403-310

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